Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Method of Estimation of Development Potential of Trade Enterprises of the System of Consumer’s Cooperative Society of Ukraine [PDF]
, 2013 The methodical recommendations for estimation of development potential of trade enterprises are developed. The scientific tool for determination of components of potential of trade enterprises and estimation of level of enterprise development potential ...
Кузьменко, Олександра Костянтинівна +1 more
core
Energy-dependent Hamiltonian in a nuclear optical model
Electronic Journal of Differential Equations, 2021 Pierre Chau Huu-Tai, Bernard Ducomet
doaj
Twist-BRD4 complex: potential drug target for basal-like breast cancer. [PDF]
Curr Pharm Des, 2015 Shi J, Cao J, Zhou BP.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Role of breast magnetic resonance imaging in predicting malignant invasion of the nipple-areolar complex: Potential predictors and reliability between inter-observers. [PDF]
Medicine (Baltimore), 2017 Liao CY +11 more
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
On an irreducible theory of complex systems
, 2008 In the paper the description of complex systems in terms of self-organization processes of prime integer relations is presented. Remarkably, based on the integers and controlled by arithmetic only the description can picture complex systems by ...
Victor Korotkikh (9811187) +3 more
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