Results 241 to 250 of about 5,831,128 (302)

Time-Resolved Electrochemical Surface-Enhanced Resonance Raman Spectroscopy Double-Fingerprint for the Detection of <i>Pseudomonas aeruginosa</i>. [PDF]

ACS Meas Sci Au
Romay L, Carcelen E, de la Parra S, Collado S, Barros R, Rumbo C, Heras A, Colina A.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice. [PDF]

J Physiol
Kalajian EJ, Stettler MK, Smith GDC, Del Negro CA.   +3 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Fast Fourier Transform Enables Automated Parametrization of Complex Dihedral Potentials in All-Atom and Coarse-Grained Force Fields. [PDF]

J Chem Inf Model
Flores-Trujillo HT, Rodríguez-Segura GL, Amador-Bedolla C, Dominguez L.   +3 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Boy in the Barrel: Excruciating Paroxysmal Pain Disorder Associated With an SCN9A Gain-of-Function Variant. [PDF]

J Peripher Nerv Syst
Tomaselli PJ, Frezatti RSS, Record CJ, Schiavoni MCL, Dominik N, Vandrovcova J, Reilly MM, Marques W.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cross-Code Verification for Improved Thermophysical Properties of Argon, Krypton and Xenon Plasmas. [PDF]

Entropy (Basel)
Vagnoni A, Murphy AB, Ghedini E.
europepmc   +1 more source

A Simplified Epicardial Ablation Strategy for Ventricular Tachycardia Integrating CT-Derived Epicardial Adipose Tissue Into Three-Dimensional Electroanatomic Mapping. [PDF]

J Cardiovasc Electrophysiol
Onuki K, Hiroshima K, Isotani A, Fukunaga M, Nagashima M, Ando K.   +5 more
europepmc   +1 more source