Results 201 to 210 of about 8,967,370 (295)

"Please speak in Hindi": Cognitive interviews to improve measurement of digital access in North India. [PDF]

PLoS One
Taluja Z, Sarangi A, Mishra P, Verma CP, Sharma M, Ummer O, Khanna A, Chamberlain S, Krishnaraj P, Hudda MS, LeFevre AE, Scott K.   +11 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Mixed pain: has pain medicine overlooked Its most common phenotype for over 20 years? A perspective on mechanistic interaction, the nociplastic paradox, and the future of pain classification. [PDF]

Front Med (Lausanne)
Freynhagen R, Alcántara Montero A.
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Trastornos de personalidad en prisión: Una cuestión compleja Personality disorders in prison: A complex question

Revista Española de Sanidad Penitenciaria, 2008
E. Álvaro Brun, M. Vegue González
doaj  

Beyond Aortic Sealing: Integrating Anatomy and Physiology in Type B Aortic Dissection. [PDF]

JACC Case Rep
Crivelaro PCF, Saadi RP.
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

A <i>de novo VPS16</i> missense variant blocks autophagic flux and extends DYT-<i>VPS16</i> into infancy. [PDF]

Autophagy Rep
Gonzalez Saez-Diez E, Xue X, Ebrahimi-Fakhari D.   +2 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

The spliceosome's secret life: pRP8 silences transposons through 3D chromatin organization. [PDF]

Plant Cell
Oya S.
europepmc   +1 more source