Results 131 to 140 of about 14,561,729 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Constructing Space: Physical versus Immaterial? Coffeehouse in the Ottoman/Turkish Society

open access: yesIconarp International Journal of Architecture and Planning, 2013
Architectural space is a complex phenomenon, comprising of physical and immaterial characteristics. Physical, together with intangible variables, define space.
Sema Soygeniş, İrem Maro Kırış
doaj   +2 more sources

Dynamical correlation functions in the Ising field theory

open access: yesSciPost Physics
We study finite temperature dynamical correlation functions of the magnetization operator in the one-dimensional Ising quantum field theory. Our approach is based on a finite temperature form factor series and on a Fredholm determinant representation of ...
István Csépányi, Márton Kormos
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

On the propagation of isotropic Sobolev singularities

open access: yesBruno Pini Mathematical Analysis Seminar
The aim of these notes is to examine the propagation of isotropic Sobolev (micro)singularities for an evolution problem whose generator is given by the Weyl quantization of a complex-valued quadratic form on phase space.
Marcello Malagutti   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Consent Form for Photography Paula Donohoe

open access: yes, 2003
Consent form for Paula Donohoe's children's appearance in photos taken for the Modbury Hospital 30th ...
Modbury Hospital
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Living Inside the UA Space Analog

open access: yes
Immediate accessThis item is made available by the University of Arizona Center for Human Space Exploration (CHaSE) with support from the University of Arizona Libraries.
Tresch, Trent
core   +4 more sources

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