Results 111 to 120 of about 14,561,729 (295)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Weighted 𝜕-Integral Representations of 𝐶𝟏-Functions in 𝐶𝑛

Journal of Function Spaces and Applications, 2012
For 𝐶1-functions 𝑓, given in the complex space 𝐶𝑛, integral representations of the form 𝑓=𝑃(𝑓)−𝑇(𝜕𝑓) are obtained. Here, 𝑃 is the orthogonal projector of the space 𝐿2{𝐶𝑛;𝑒−𝜎|𝑧|𝜌|𝑧|𝛾𝑑𝑚(𝑧)} onto its subspace of entire functions and the integral operator 𝑇
Arman H. Karapetyan
doaj   +1 more source

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity [PDF]

, 2011
hSSB1 is a recently discovered single-stranded DNA binding protein that is essential for efficient repair of DNA double-strand breaks (DSBs) by the homologous recombination pathway.
Dinoop Menon, Cubeddu, Liza (R16726), Bain, Amanda, White, Malcolm F., Emma Bolderson, Urquhart, Aaron J., Aaron J. Urquhart, Bolderson, Emma, Khanna, Kum Kum, Menon, Dinoop, Derek J. Richard, Amanda Bain, Malcolm F. White, Richard, Derek J., Kum Kum Khanna, Liza Cubeddu, Cubeddu, Liza   +16 more
core   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

W7-curvature tensor on a complex contact space form

This article aims to examine the curvature properties of the W7-curvature tensor ona complex contact space form. We examine a complex contact space form under theW7-curvature tensor’s W7-flat, ξ-W7-flat, GH-W7-flat, GH-W7-semi-symmetric,W7Q and W7(ξ, K)S
Vanlı, Aysel, Alkaya, Gamze
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Kähler Magnetic Curves in Conformally Euclidean Schwarzschild Space

Cumhuriyet Science Journal
In this paper, we study the magnetic curves on a Kähler manifold which is conformally equivalent to Euclidean Schwarzschild space. We show that Euclidean Schwarzschild space is locally conformally Kähler and transform it into a Kähler space by applying a
Özgür Kelekçi
doaj   +1 more source