Results 101 to 110 of about 14,606,458 (293)
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Orthogonal-Array based Design Methodology for Complex, Coupled Space Systems [PDF]
The process of designing a complex system, formed by many elements and sub-elements interacting between each other, is usually completed at a system level and in the preliminary phases in two major steps: design-space exploration and optimization.
Mooij, Erwin +4 more
core
An Immersion of an $n$-dimensional Real Space Form into an $n$-dimensional Complex Space Form
Let \(M\) be an \(n\)-dimensional submanifold of an \(m\)-dimensional Riemannian manifold \(N\) and \(H\) be the mean curvature vector of \(M\). Let \(\zeta_ x\) be \(m-n\) mutually orthogonal unit normal vector fields of \(M\) such that \(H=| H|_{\zeta_ 1}\). The normal vector \(a(H)\) defined by \[ a(H)=(| H| /n)\sum^{m-n}_{x=2}Tr(A_ 1 A_ x)\zeta_ x \
openaire +3 more sources
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
W8-Curvature tensor on a complex contact space form
In this paper, we study the curvature properties of the W8-curvature tensor on a complex contact space form. The conditions for a complex contact space form to be ζ-W8-flat, GH-W8-semi-symmetric, W8Q = 0, and W8(ζ,C1) S= 0 are investigated.
VANLI, AYSEL, Alkaya, Gamze
core +1 more source
The repulsive Coulomb force poses severe challenges when describing (d, p) reactions for highly charged nuclei as a three-body problem. Casting Faddeev-AGS equations in a Coulomb basis avoids introducing screening of the Coulomb force.
Eremenko V. +6 more
doaj +1 more source
Prospecting the protein design landscape
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source

