Results 101 to 110 of about 14,561,729 (295)
Orthogonal-Array based Design Methodology for Complex, Coupled Space Systems [PDF]
, 2010 The process of designing a complex system, formed by many elements and sub-elements interacting between each other, is usually completed at a system level and in the preliminary phases in two major steps: design-space exploration and optimization.
Mooij, Erwin +4 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
An Immersion of an $n$-dimensional Real Space Form into an $n$-dimensional Complex Space Form
Tokyo Journal of Mathematics, 1986 Let \(M\) be an \(n\)-dimensional submanifold of an \(m\)-dimensional Riemannian manifold \(N\) and \(H\) be the mean curvature vector of \(M\). Let \(\zeta_ x\) be \(m-n\) mutually orthogonal unit normal vector fields of \(M\) such that \(H=| H|_{\zeta_ 1}\). The normal vector \(a(H)\) defined by \[ a(H)=(| H| /n)\sum^{m-n}_{x=2}Tr(A_ 1 A_ x)\zeta_ x \
openaire +3 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
EPJ Web of Conferences, 2016 The repulsive Coulomb force poses severe challenges when describing (d, p) reactions for highly charged nuclei as a three-body problem. Casting Faddeev-AGS equations in a Coulomb basis avoids introducing screening of the Coulomb force.
Eremenko V. +6 more
doaj +1 more source
W8-Curvature tensor on a complex contact space form
In this paper, we study the curvature properties of the W8-curvature tensor on a complex contact space form. The conditions for a complex contact space form to be ζ-W8-flat, GH-W8-semi-symmetric, W8Q = 0, and W8(ζ,C1) S= 0 are investigated.
VANLI, AYSEL, Alkaya, Gamze
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Geometry of conformal vector fields
Arab Journal of Mathematical Sciences, 2017 It is well known that the Euclidean space (Rn,〈,〉), the n-sphere Sn(c) of constant curvature c and Euclidean complex space form (Cn,J,〈,〉) are examples of spaces admitting conformal vector fields and therefore conformal vector fields are used in ...
Sharief Deshmukh
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source