Results 121 to 130 of about 1,107,302 (294)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

ANALYTICAL SOLUTION OF STRESS INTENSITY FACTOR FOR MULTIPLE ELLIPTICAL HOLE EDGE CRACKS

Jixie qiangdu
The aging aircraft fuselage skin contains multiple hole edge cracks,and the skin holes will change from circular holes to elliptical holes under loads.The calculation of stress intensity factors for multiple elliptical hole edge cracks is an important ...
doaj  

Red-Leafed Lettuces: Genetic Variation or Epigenetic Photomorphogenesis?

Plants
Red-leaf lettuces, rich in bioactive compounds like anthocyanins and flavonoids, offer health benefits by reducing oxidative stress and boosting immunity.
Natalya V. Smirnova, Ivan A. Timofeenko, Konstantin V. Krutovsky   +2 more
doaj   +1 more source

Boundary force method for analyzing two-dimensional cracked bodies [PDF]

The Boundary Force Method (BFM) was formulated for the two-dimensional stress analysis of complex crack configurations. In this method, only the boundaries of the region of interest are modeled. The boundaries are divided into a finite number of straight-
Newman, J. C., Jr., Raju, I. S., Tan, P. W.   +2 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Validation and Verification of Novel Three-Dimensional Crack Growth Simulation Software GmshCrack3D

Applied Sciences
The accurate prediction of crack initiation and propagation is essential for assessing the structural integrity of mechanically joined components and other complex assemblies. To overcome the limitations of existing finite element tools, a modular Python
Sven Krome, Tobias Duffe, Gunter Kullmer, Britta Schramm, Richard Ostwald   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Recent trends in transcriptional regulation of cold stress tolerance in plants

Discover Sustainability
Plants are frequently exposed to a wide variety of environmental stressors, including heat, salinity, cold, drought, heavy metals, and other abiotic stresses. These stresses have a significant impact on the productivity, growth, and development of plants.
Kapil Gupta, Shabir H. Wani, Ali Razzaq, Vincent Pamugas Reyes, Neeraj Kumar Dubey, Jogeswar Panigrahi, Avneesh Kumar, Simranjeet Kaur, Mehdi Rahimi, Anuj Kumar, Gourav Choudhir   +10 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source