Results 101 to 110 of about 1,107,302 (294)

Experimental and numerical investigation into effect of elevated temperature on fretting fatigue behavior [PDF]

, 2011
Fretting fatigue damage occurs in contacting parts when they are subjected to fluctuating loadings and sliding movements at the same time. This phenomenon may occur in many applications such as bearings/ shafts, bolted and riveted connections, steel ...
Abdel Wahab, Magd, De Baets, Patrick, Hojjati Talemi, Reza, Soori, M   +3 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Pengaruh Faktor Sosial terhadap Intensi Bermain Judi Online: Peran Moderasi Kecerdasan Emosional

Jurnal Sosial Humaniora
This study investigates the prevalence of online gambling and its significant impact on individuals, with many falling victims to its addictive nature.
Sadikin Sadikin
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Risk factors of metatarsal stress fracture associated with repetitive sports activities: a systematic review

Frontiers in Bioengineering and Biotechnology
BackgroundMetatarsal stress fracture is common in people engaged in repetitive weight-bearing activities, especially athletes and recruits. Identifying risk factors in these contexts is crucial for effective prevention.MethodsA systematic search on Web ...
Jiayi Sun, Jiayi Sun, Chenglong Feng, Yaming Liu, Mianjia Shan, Zilin Wang, Weijie Fu, Wenxin Niu   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Modeling of the Complexity Propagation of Crack in a Ductile Material Under Complex Solicitation in Crack Tip: Introduction of a Matrix of Stress Intensity Factors of Bifurcation

American Journal of Applied Mathematics
In fracture and damage mechanics, modeling of crack propagation has always been a source of difficulties. Numerous works have been carried out on this case at the crack tip, introducing new parameters: the Stress Intensity Factor (K); which is the local Irwin parameter, and also the Rice integral (J), the Griffith's energizing method, in which
Pierre Pola, Guy Ntamack, Fabien Kenmogne, Joseph Effa, Stephane Tchuente   +4 more
openaire   +1 more source

Ergonomic provision of modernizing management processes of metallurgical production in Ukraine and China [PDF]

, 2017
Purpose. The creation ofan ergonomic methodical approach to the modernization of management processes of metallurgical production, which involves a human factor while developing and exploiting the difficult man-machine system and estimating the degree of
Krupskyi, Oleksandr, Shevyakov, Оlexey, Slavska, Ynina   +2 more
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