Results 81 to 90 of about 1,107,302 (294)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Hot ductility of TiNb IF steel slab after hot torsion testing [PDF]

, 2019
The aim of the work was to evaluate the hot ductility loss in TiNb stabilized IF steel directly from the continuously-cast slab using hot torsion testing (plastometry) in the temperature range 600-1250 degrees C according to the basic programme, and also
Bořuta, Aleš, Dobrovská, Jana, Fujda, Martin, Girman, Vladimír, Jonšta, Petr, Jonšta, Zdeněk, Konrádyová, Jana, Longauer, Svätoboj, Longauerová, Margita, Matvija, Miloš, Vojtko, Marek   +10 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Stress Concentrations in Non-Homogeneous Elastic Layer Weakened by Cracks

Engineering Transactions, 1979
The paper presents the statical problem of stress concentrations around the tips of two semi-infinite cracks situated within an infinite, non-homogenous elastic layer. The conditions of antiplane state of strain are assumed to be satisfied.
M. Matczyński
doaj  

Stress and periodontal disease: The link and logic!!

Industrial Psychiatry Journal, 2013
Stress is an equated response to constant adverse stimuli. At one point or another everybody suffers from stress. Stress is compatible with good health, being necessary to cope with the challenges of everyday life. Problems start when the stress response
Sachin Goyal, Garima Gupta, Betsy Thomas, K M Bhat, G S Bhat   +4 more
doaj   +1 more source

Velocity Fluctuations in Dynamical Fracture: the Role of Microcracks

, 2004
We address the velocity fluctuations of fastly moving cracks in stressed materials. One possible mechanism for such fluctuations is the interaction of the main crack with micro cracks (irrespective whether these are existing material defects or they form
D. A. Kessler, David Kessler, E. Sharon, Eran Bouchbinder, Itamar Procaccia, K. B. Broberg, L. B. Freund, L. I. Slepyan, M. Abramowitz, Sh. A. Kulamekhmetova, W. H. Press   +10 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Mode I Stress Intensity Factors for triangular corner crack nearby intersecting of cylindrical holes

Fracture and Structural Integrity, 2013
The paper deals with the Stress Intensity Factor assessment of cracks at the intersection of holes loaded by internal pressure. Triangular flaws are considered at the intersection of two holes inside a specific specimen.
E. Salvati, P. Livieri, R. Tovo
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source