Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Environmental dependence of visible anthocyanin accumulation mediated by the CmMYB6–CmbHLH2 complex
Frontiers in Plant ScienceThe anthocyanin biosynthesis pathway has been investigated as a candidate for visual reporting in plants, due to its pigment-producing capacity. Activation of this pathway is predominantly regulated by MYB-bHLH regulatory complexes.
Qiwei Deng +9 more
doaj +1 more source
Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]
, 2017 Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A +3 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Сoncentrated force acting near the tip of an interface crack with a rigid overlay on its side
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 Plane stress state near the tip of an interface crack induced by specified concentrated force is considered. One of the crack faces is partially reinforced by a rigid straight line overlay.
Yulia O Vasilyeva, Vasiliy V Silvestrov
doaj
The psychological impact of motor vehicle accidents : a New Zealand study : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Psychology at Massey University [PDF]
, 1997 PLEASE NOTE Pages 72-73 are missing from the original copyThe present research attempted to identify those factors which predispose victims of severe motor vehicle accidents to develop PTSD, and explored the relationship between mental health and health ...
Kennedy-Moffat, James
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Finite Element Computations of Complex Stress Intensity Factor Magnitude of Interfacial Crack in Bi-Material Composites [PDF]
International Conference on Aerospace Sciences and Aviation Technology, 2015 Composite structures are distinguished by interfaces separating their different layers. These interfaces represent region of mismatches in mechanical and thermal properties of the adjacent layers. These regions are rich in cracks which are laying either on or sub- the interface in a direction parallel or perpendicular to it.
openaire +1 more source
A novel weight function for RMS stress intensity factor determination in surface cracks [PDF]
, 2010 This paper discusses the problem of stress intensity factor determination in surface cracks. In particular, the concept of root mean square stress intensity factors (RMS SIF) is discussed for the general class of semi-elliptical surface cracks.
Brennan, Feargal P. +1 more
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source