Results 51 to 60 of about 1,217,820 (328)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

COMPLEX VARIABLE FUNCTION SOLUTIONS OF MIXED-MODE STRESS INTENSITY FACTORS FOR TWO CRACKS OF ARBITRARY LENGTH EMANATING FROM AN ELLIPTICAL HOLE

Jixie qiangdu, 2019
In order to calculate the stress intensity factors of two-dimensional cracks emanating from elliptical hole, a solution method for stress intensity factor based on Muskhelishvili complex function theory and truncated conformal mapping approach is ...
ZHU QingYu, ZHOU Rui
doaj  

Rapid estimation of notch stress intensity factors in 3D large-scale welded structures using the peak stress method

, 2018
The Peak Stress Method (PSM) is an engineering, FE-oriented application of the notch stress intensity factor (NSIF) approach to fatigue design of welded joints, which takes advantage of the singular linear elastic peak stresses from FE analyses with ...
A. Campagnolo, G. Meneghetti
semanticscholar   +1 more source

Mutiple curved crack problems in antiplane elasticity for circular region with traction free boundary [PDF]

, 2013
The multiple curved cracks in a circular region problem in antiplane elasticity is formulated in terms of hypersingular integral equation in conjunction with the complex variable function method. The obtained hypersingular integral equations are solved
Dahalan, Noraini, Eshkuvatov, Zainidin K., Nik Long, Nik Mohd Asri   +2 more
core  

Development of a fretting-fatigue mapping concept: The effect of material properties and surface treatments [PDF]

, 2009
Fretting-fatigue induced by combined localized cyclic contact motion and external bulk fatigue loadings may result in premature and dramatic failure of the contacting components.
Araújo, Araújo, Bueckner, Crossland, Dang Van, Dini, El Haddad, Fouvry, Fouvry, Fouvry, Fouvry, Fouvry, Fouvry, Fouvry, Giannakopoulos, Hills, Hills, Hills, Johnson, K. Kubiak, Kitagawa, Kubiak, McDiarmid, Mindlin, Mugadu, Nowell, Nowell, Proudhon, S. Fouvry, Szolwinski, Taylor, Waterhouse, Zhou   +32 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Dynamic Crack Propagation Problems of Fibre-Reinforced Concrete

Advances in Civil Engineering, 2012
Applying the built dynamic crack model of fibre concrete, bridging fiber segment is substituted by loads. When a crack propagates its fiber continues to break.
Y. H. Cheng, Lu Nian Chun, Li Xin-gang
doaj   +1 more source

General criterion for intersection between hydraulic induced fractures and pre-existing natural fractures

Petroleum, 2019
Pre-existing natural fractures and other structurally weak planes are usually well-developed in unconventional reservoirs. When such fractures intersect with hydraulic induced fractures, they will redirect and propagate as an important mechanical ...
Zhifeng Luo, Nanlin Zhang, Liqiang Zhao, Fei Liu, Nianyin Li   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The role of stress in IBS symptom severity

Psychological Topics, 2016
Irritable bowel syndrome is regarded as a biopsychosocial disorder, the result of a complex combination of predisposing, precipitating and perpetuating factors. Personality traits, affective status and stress are some of the relevant factors contributing
Sanda Pletikosic, Mladenka Tkalčić
doaj   +2 more sources