Results 41 to 50 of about 471,455 (198)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Almost complex surfaces in the nearly Kaehler S6
International Journal of Mathematics and Mathematical Sciences, 1992 It is shown that a compact almost complex surface in S6 is either totally geodesic or the minimum of its Gaussian curvature is less than or equal to 1/3.
Sharief Deshmukh
doaj +1 more source
Comparison of WBGTs over Different Surfaces within an Athletic Complex
Medicina, 2020 Many athletic governing bodies are adopting on-site measurement of the wet-bulb globe temperature (WBGT) as part of their heat safety policies. It is well known, however, that microclimatic conditions can vary over different surface types and a question ...
Andrew Grundstein, Earl Cooper
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Biharmonic and Quasi-Biharmonic Slant Surfaces in Lorentzian Complex Space Forms
Abstract and Applied Analysis, 2013 In 1991, Chen and Ishikawa initially studied biharmonic marginally trapped surfaces in neutral pseudo-Euclidean 4-space. Recently, biharmonic and quasi-biharmonic marginally trapped Lagrangian surfaces in Lorentzian complex space forms were studied by ...
Yu Fu
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Casa para el poema del ángulo recto, Vilches, Chile
ARQ, 2012 Superficies complejas construidas -y revestidas- con tablas, una losa abombada y tres conos truncados dan forma a un interior recogido y a un volumen en sombras.A domed slab, complex surfaces -cast and lined with planks- and three truncated cones shape a
Smiljan Radic
doaj
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source