Results 61 to 70 of about 471,455 (198)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Complicate Observations and Multi-Parameter Land Information Constructions on Allied Telemetry Experiment (COMPLICATE).

PLoS ONE, 2015
The Complicate Observations and Multi-Parameter Land Information Constructions on Allied Telemetry Experiment (COMPLICATE) comprises a network of remote sensing experiments designed to enhance the dynamic analysis and modeling of remotely sensed ...
Xin Tian, Zengyuan Li, Erxue Chen, Qinhuo Liu, Guangjian Yan, Jindi Wang, Zheng Niu, Shaojie Zhao, Xin Li, Yong Pang, Zhongbo Su, Christiaan van der Tol, Qingwang Liu, Chaoyang Wu, Qing Xiao, Le Yang, Xihan Mu, Yanchen Bo, Yonghua Qu, Hongmin Zhou, Shuai Gao, Linna Chai, Huaguo Huang, Wenjie Fan, Shihua Li, Junhua Bai, Lingmei Jiang, Ji Zhou   +27 more
doaj   +1 more source

Autonomous Trajectory Planning for Spray Painting on Complex Surfaces Based on a Point Cloud Model. [PDF]

Sensors (Basel), 2023
Nieto Bastida S, Lin CY.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A soft microrobot with highly deformable 3D actuators for climbing and transitioning complex surfaces. [PDF]

Proc Natl Acad Sci U S A, 2022
Pang W, Xu S, Wu J, Bo R, Jin T, Xiao Y, Liu Z, Zhang F, Cheng X, Bai K, Song H, Xue Z, Wen L, Zhang Y.   +13 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An adaptive and versatile method to quantitate and characterize collective cell migration behaviors on complex surfaces. [PDF]

Front Cell Dev Biol, 2023
Loesel KE, Hiraki HL, Baker BM, Parent CA.   +3 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

FPI Based Hyperspectral Imager for the Complex Surfaces-Calibration, Illumination and Applications. [PDF]

Sensors (Basel), 2022
Raita-Hakola AM, Annala L, Lindholm V, Trops R, Näsilä A, Saari H, Ranki A, Pölönen I.   +7 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source