Results 121 to 130 of about 15,720,626 (306)

Complex stochastic boolean systems: comparing bitstrings with the same hamming weight [PDF]

, 2014
A complex stochastic Boolean system (CSBS) is a complex system depending on an arbitrarily large number n of random Boolean variables. CSBSs arise in many different areas of science and engineering.
González Sánchez, Luis
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

New England Complex Systems Institute

, 2003
The New England Complex Systems Institute (NECSI) is an independent educational and research institution dedicated to advancing the study of complex systems.

core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Typical thermalization of low-entanglement states

Communications Physics
Proving thermalization from the unitary evolution of closed quantum systems is one of the oldest questions that is still only partially resolved.
Christian Bertoni, Clara Wassner, Giacomo Guarnieri, Jens Eisert   +3 more
doaj   +1 more source

Chaos and dynamical systems Primers in complex systems./ David P. Feldman.

, 2019
Includes bibliographical references and index.Chaos and Dynamical Systems presents an accessible, clear introduction to dynamical systems and chaos theory, an important and exciting area that has shaped many scientific fields.
Feldman David P.,
core  

Complex Interventions for a Complex System? Using Systems Thinking to Explore Ways to Address Unhealthy Commodity Industry Influence on Public Health Policy [PDF]

Background Interventions are needed to prevent and mitigate unhealthy commodity industry (UCI) influence on public health policy. Whilst literature on interventions is emerging, current conceptualisations remain incomplete as they lack considerations of
Gilmore, Anna, Bondy, Krista, Van Den Akker, Amber, Dance, Sarah, Matthes, Britta, Nobles, James, Akker, Amber Van Den, Zatonski, Mateusz, Bertscher, Adam, Bloomfield, Michael J   +9 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Heterogeneous Multidimensional Colonel Blotto: Framework and Equilibrium Structure

Mathematics
Classical Colonel Blotto models predict smooth and monotone allocation patterns under a homogeneous-resource benchmark. This paper studies how heterogeneous technologies and partially irreversible deployment reshape equilibrium structure through a ...
Yuanyuan Zhang, Gang Xiao, Feng Ye, Lingtao Xue, Zhipeng Du, Tong Li   +5 more
doaj   +1 more source