Results 111 to 120 of about 7,998,614 (283)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Statistical ensembles without typicality

Nature Communications, 2018
The minimal amount of assumptions to justify the use of maximum-entropy ensembles is still debated. Here, the authors show that the transitions that a partially known system environment can undergo are the same allowed for the maximum entropy state which
Paul Boes, Henrik Wilming, Jens Eisert, Rodrigo Gallego   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Measuring out quasi-local integrals of motion from entanglement

Communications Physics
Quasi-local integrals of motion are a key concept underpinning the modern understanding of many-body localisation, a phenomenon in which interactions and disorder come together.
Bohan Lu, Christian Bertoni, Steven J. Thomson, Jens Eisert   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Atomic mechanisms of full-length ASC-mediated inflammasome assembly

Nature Communications
ASC (Apoptosis-associated Speck-like protein containing a CARD) is a key adaptor protein that assembles inflammasomes by linking sensors such as NLRP3 to effectors like Caspase-1 via its PYD and CARD Death Domains.
Dongmei Xue, Fengyun Ni, Sheng Liu, Huifang Yan, Zhenwei Luo, Gang Fu, Qinghua Wang, Jianpeng Ma   +7 more
doaj   +1 more source

Critical Phenomena and Diffusion in Complex Systems

, 2008
Editorial of the International Conference on Critical Phenomena and Diffusion in Complex Systems held on 5--7 December, 2006 in Nizhniy Novgorod State University, Russia and was dedicated to the memory and 80th anniversary of Professor Askold N. Malakhov.
Dubkov, Alexander A., Spagnolo, Bernardo
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

High power, dual SWIR-MIR OPCPA source for high-order harmonics generation

Scientific Reports
High-harmonic generation (HHG) spectroscopy enables the observation of fundamental ultrafast phenomena in nature. Recent advances in laser technology have led to the development of wavelength tunable ultrashort light sources, allowing the study of a wide
Barry D. Bruner, Raman Maksimenka, Nicolas Thiré, Lior Faeyrman, Roni Weiss, Noa Avni, Talya Arusi-Parpar, Yoann Pertot, Nirit Dudovich   +8 more
doaj   +1 more source