Results 161 to 170 of about 2,293,654 (219)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Localizing Synergies of Hidden Factors in Complex Systems: Resting Brain Networks and HeLa GeneExpression Profile as Case Studies. [PDF]

Entropy (Basel)
Ontivero-Ortega M, Mijatovic G, Faes L, Rosas FE, Marinazzo D, Stramaglia S.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A Synergistic Perspective on Multivariate Computation and Causality in Complex Systems. [PDF]

Entropy (Basel)
Varley TF.
europepmc   +1 more source

Understanding complex systems through differential causal networks. [PDF]

Sci Rep
Defilippo A, Giorgi FM, Veltri P, Guzzi PH.   +3 more
europepmc   +1 more source

Challenges and opportunities for digital twins in precision medicine from a complex systems perspective. [PDF]

NPJ Digit Med
De Domenico M, Allegri L, Caldarelli G, d'Andrea V, Di Camillo B, Rocha LM, Rozum J, Sbarbati R, Zambelli F.   +8 more
europepmc   +1 more source

A complex systems approach to mosaic loss of the Y chromosome. [PDF]

Geroscience
Guo X, Dai X.
europepmc   +1 more source

Generative learning for forecasting the dynamics of high-dimensional complex systems. [PDF]

Nat Commun
Gao H, Kaltenbach S, Koumoutsakos P.
europepmc   +1 more source

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Complex systems

Proceedings International Conference and Workshop on Engineering of Computer-Based Systems, 2002
Every organisation from the scale of whole countries down to small companies has a list of system developments which have ended in various forms of disaster. The nature of the failures varies but typical examples are: cost overruns; timescale overruns and sometimes, loss of life.
Barry Keepence, Mike Mannion
openaire   +2 more sources