Results 171 to 180 of about 15,720,626 (306)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Interactions Between Antioxidants: How Useful Are In Vitro Studies for Understanding the Action of Antioxidants in Complex Systems? [PDF]

Int J Mol Sci
Sadowska-Bartosz I, Bartosz G.
europepmc   +1 more source

Reinforcement learning to influence the emerging behaviors of complex systems

reservedThis thesis investigates the control of simulated agent-based models using reinforcement learning (RL). Self-organizing systems, where interacting individuals exhibit complex and emergent patterns, can undergo phase transitions based on parameter
PITTERI, ALESSIO
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Event-based spatiotemporal networks for modelling emergent phenomena in complex systems. [PDF]

Nat Commun
Romeijnders M, van Boven M, Corman F, Modes CD, Staniczenko PPA, Panja D.   +5 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

New directions for complex systems in contemporary neuroscience: a morphodynamic and emergent function approach. [PDF]

Front Comput Neurosci
Oruro EM, Pardo GE, Rasia-Filho AA, Garcia-Cairasco N.   +3 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Analyzing the item-level effects of emotion regulation through a complex systems approach. [PDF]

J Educ Health Promot
Zadehparizi R, Kianimoghadam AS, Mohajerin B, Masjedi Arani A, Bakhtiari M, Hashemi M.   +5 more
europepmc   +1 more source

System Metamodelling of Open-Ended Evolution Implemented with Self-Modifying Code

, 2023
Christen, Patrik
core   +1 more source