Results 191 to 200 of about 15,720,626 (306)

From diagnosis to dynamics: complex systems, transdiagnostics, and networks in forensic psychiatry. [PDF]

Front Psychol
Bogaerts S, Masthoff E, Frowijn I, De Caluwé E, Habets P, Janković M, Smith L.   +6 more
europepmc   +1 more source

Timeliness criticality in complex systems

In complex systems, external parameters often determine the phase in which the system operates, that is, its macroscopic behaviour. For nearly a century, statistical physics has been used to extensively study systems’ transitions across phases ...
Morán, José, Panja, Deb, Pijpers, Frank, Romeijnders, Matthijs, Weitzel, Utz, Sub Simulation of Complex Systems, Bouchaud, Jean-Philippe, Pierre, Le Doussal, Simulation of Complex Systems   +8 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Complex systems science in the AI era: a pivotal paradigm for scientific research. [PDF]

Natl Sci Rev
Yang M, Zhao W.
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Improving complex systems with improve-mentation: challenges and solutions. [PDF]

Front Health Serv
Ovretveit J.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Reviewing ecosystems of evidence: synthesising the evidence on the commercial determinants of health from a complex systems perspective. [PDF]

Syst Rev
Tompson A, Thomas J, Rutter H, Blanchard L, Cott É, Glover RE, Knai C, Maani N, van Schalkwyk MCI, Welch V, Petticrew M.   +10 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

RSM-Optimized Ultrasonic-Assisted Extraction for High-Efficiency Recovery of Pb, Cd, and As in Complex Systems. [PDF]

ACS Omega
Klinpratoom B, Sricharoen P, Nateewattana J, Chansuvarn W, Amnuaywattanakul T, Kanthang P, Kuttiyawong A, Meechai T, Nakyai W, Suksri K, Nuengmatcha P, Limchoowong N.   +11 more
europepmc   +1 more source