Editorial: Interdisciplinary approaches to complex systems: highlights from FRCCS 2023/24. [PDF]
Front Big DataInterdonato R, Cherifi H.
europepmc +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Beyond the Brushstrokes-Illuminating Patterns and Interactions to Find Order in Complex Systems. [PDF]
Emerg Infect DisMacCannell D, MacInnis B, Santibanez S.
europepmc +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Integrating the Contrasting Perspectives Between the Constrained Disorder Principle and Deterministic Optical Nanoscopy: Enhancing Information Extraction from Imaging of Complex Systems. [PDF]
Bioengineering (Basel)Ilan Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Transfer Learning and Permutation-Invariance Improving Predicting Genome-Wide, Cell-Specific and Directional Interventions Effects of Complex Systems. [PDF]
Adv Sci (Weinh)Wang B, Pan B, Zhang T, Liu Q, Li S.
europepmc +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems. [PDF]
Sci RepZhang X +7 more
europepmc +1 more source
Local Difference Measures between Complex Networks for Dynamical System Model Evaluation
, 2015 Stefan Lange +3 more
openalex +2 more sources