Results 191 to 200 of about 7,947,791 (315)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Quasi-differentiation and its applications to noisy time series data from complex systems. [PDF]

Sci Rep
Cheong SA, Kang ZT, Yen PT.
europepmc   +1 more source

Synchronization of Complex System by Designing a Controller

Komal, Ishu, Geeta, Ejaz
openalex   +2 more sources

DEVELOPMENT OF FORMATION PRINCIPLES OF A MULTI-LEVEL SYSTEM TO EVALUATE THE QUALITY OF EQUIPMENT OPERATED IN THE AGRO-INDUSTRIAL COMPLEX

, 2023
Sergey Gaydar, Rustam Mirzaev, Anna Pikina   +2 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Correction: An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems. [PDF]

Sci Rep
Zhang X, Zhang Q, Zhao Q, Zhao S, Zhao Y, Guo Y, Zhao Z, Song L.   +7 more
europepmc   +1 more source

Application of Davidson-Cole Function to Complex Dynamic Light Scattering Spectroscopy in Frequency Domain for Nonionic Surfactant Systems in Isotropic Phase

Shinsaku Takagi, K. Miyauchi, Sae Kurabe, Saki Kobashi   +3 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Synchronizations in Complex Systems Dynamics Through a Multifractal Procedure. [PDF]

Entropy (Basel)
Ghizdovat V, Mirila DC, Nedeff F, Rusu DI, Rusu O, Agop M, Vasincu D.   +6 more
europepmc   +1 more source

ON A MATURITY MODEL FOR COMPLEXITY, COMPLEX SYSTEMS, AND COMPLEX SYSTEMS ENGINEERING

International Journal of Design & Nature and Ecodynamics, 2016
openaire   +1 more source