Results 211 to 220 of about 2,361,537 (287)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Dynamical theory of complex systems with two-way micro-macro causation. [PDF]

Proc Natl Acad Sci U S A
Harte J, Brush M, Umemura K, Muralikrishnan P, Newman EA.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The Power of a Complex Systems Perspective to Elucidate Aging. [PDF]

J Gerontol A Biol Sci Med Sci
Cohen AA, Olde Rikkert MGM.
europepmc   +1 more source

The algorithm of selection of non-traditional renewable sources of electric energy in the local power supply system of enterprises of mining complex

, 2016
Serhii Boiko, Ю. А. Минаков, О.М. Sinchuk, І.О. Sinchuk   +3 more
openalex   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Complex systems perspective in assessing risks in artificial intelligence. [PDF]

Philos Trans A Math Phys Eng Sci
Kondor D, Hafez V, Shankar S, Wazir R, Karimi F.   +4 more
europepmc   +1 more source

The Ogooue Fan (Gabon): a modern example of deep-sea system on a complex sea-floor topography

, 2018
Salomé Mignard, Thierry Mulder, Philippe Martinez, Thierry Garlan   +3 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A Synergistic Perspective on Multivariate Computation and Causality in Complex Systems. [PDF]

Entropy (Basel)
Varley TF.
europepmc   +1 more source