Results 51 to 60 of about 2,361,537 (287)

Spliceator: multi-species splice site prediction using convolutional neural networks

BMC Bioinformatics, 2021
Background Ab initio prediction of splice sites is an essential step in eukaryotic genome annotation. Recent predictors have exploited Deep Learning algorithms and reliable gene structures from model organisms.
Nicolas Scalzitti, Arnaud Kress, Romain Orhand, Thomas Weber, Luc Moulinier, Anne Jeannin-Girardon, Pierre Collet, Olivier Poch, Julie D. Thompson   +8 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The Competing Two-Strain SIS Pairwise Approximation Model With Infection Age

IEEE Access, 2019
This paper studies a two-strain SIS pairwise approximation model with a competing mechanism and non-Markovian recovery process in which the recovery rate depends on infection age.
Juping Zhang, Dan Li, Wenjun Jing, Zhen Jin   +3 more
doaj   +1 more source

Terahertz waves dynamic diffusion in 3D printed structures

Scientific Reports, 2022
Applications of metamaterials in the realization of efficient devices in the terahertz band have recently been considered to achieve wave deflection, focusing, amplitude manipulation and dynamical modulation.
Mauro Missori, Laura Pilozzi, Claudio Conti   +2 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Topic detection with recursive consensus clustering and semantic enrichment

Humanities & Social Sciences Communications, 2023
Extracting meaningful information from short texts like tweets has proved to be a challenging task. Literature on topic detection focuses mostly on methods that try to guess the plausible words that describe topics whose number has been decided in ...
Vincenzo De Leo, Michelangelo Puliga, Marco Bardazzi, Filippo Capriotti, Andrea Filetti, Alessandro Chessa   +5 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Data-Driven Quality Assurance: Defect Prediction to Reduce Carbon Footprint in Manufacturing Logistics [PDF]

E3S Web of Conferences
In modern manufacturing environments, minimizing carbon emissions while maintaining product quality has become a strategic imperative. One critical yet often overlooked contributor to elevated CO₂ emissions is the occurrence of unexpected quality defects,
Douiri Rokaya, Taraa Chaymae, Elmoussami Haj, Ezzine Latifa   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

Nature Communications, 2018
DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the ...
Sjors P. W. Wijnands, Wouter Engelen, René P. M. Lafleur, E. W. Meijer, Maarten Merkx   +4 more
doaj   +1 more source