Results 191 to 200 of about 6,096,882 (294)

Value-Based Outsourcing Is Associated with Improved Healthcare Outcomes in Low- and Intermediate-Complexity European Hospitals: A Cross-Sectional Study from Spain. [PDF]

Healthcare (Basel)
Short Apellaniz J, Pfang B, Blanco Rubio Á, Pascual A, Maestre Mulas I, Barba-Martín R, Jiménez Á, Nuñez García A, Álvaro de la Parra JA, Del Olmo Rodríguez M.   +9 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Retracted: Optimization of Clinical Nursing Management System Based on Data Mining

Complexity
null Complexity
doaj   +1 more source

Simplicity and Complexity in Combinatorial Optimization. [PDF]

Entropy (Basel)
Dingle K, Hutter M.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Retracted: Personalized Recommendation Model of High-Quality Education Resources for College Students Based on Data Mining

Complexity
null Complexity
doaj   +1 more source

Advanced channel estimation in OTFS and NOMA using deep bayesian gaussian processes and compressive sensing. [PDF]

Sci Rep
Anilkumar N, Sengan S.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Retracted: Application Research of Intelligent Classification Technology in Enterprise Data Classification and Gradation System

Complexity
null Complexity
doaj   +1 more source

Transvenous lead extraction: predictors of procedure complexity. [PDF]

Open Heart
Csillik A, Gagyi R, Szőllősi GJ, Kardos A, Földesi C, Som Z, Vamos M, Nemes A, Saghy L, Szili-Torok T.   +9 more
europepmc   +1 more source