Results 91 to 100 of about 51,577 (270)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Blind Adaptive Beamformer Based on Orthogonal Projections for GNSS

, 2012
The quality of the ranging data provided by a global navigation satellite systems (GNSS) receiver largely depends on the synchronization error, that is, on the accuracy of the propagation time-delay estimation of the line-of-sight (LOS) signal.
Noll, Tobias G., Meurer, Michael, Antreich, Felix, Sgammini, Matteo, Kurz, Lothar   +4 more
core  

Optimal power allocation in spatial MIMO channel using heuristic algorithms

Majlesi Journal of Electrical Engineering
The topic of power allocation in MIMO systems for wireless communication in order to reach high capacity or low bit error rate has gained some attention.
Javad Zeraatkar Moghaddam, Hamid Farrokhi   +1 more
doaj  

A New Trajectory-Planning Beetle Swarm Optimization Algorithm for Trajectory Planning of Robot Manipulators

IEEE Access, 2019
Based on a heuristic optimization algorithm, this paper proposes a new algorithm named trajectory-planning beetle swarm optimization (TPBSO) algorithm for solving trajectory planning of robots, especially robot manipulators.
Lei Wang, Qing Wu, Fei Lin, Shuai Li, Dechao Chen   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A Low-Complexity Subcarrier-Power Allocation Scheme for Frequency-Division Multiple-Access Systems

, 2010
This letter aims to design a low-complexity subcarrier-power allocation scheme to improve the communication reliability of various types of frequency-division multiple-access (FDMA) systems. Both uplink and downlink are considered.
Yang, Lie-Liang, Liu, Tingting, Yang, Chenyang   +2 more
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Tree-based reparameterization with distributional approximations for reduced-complexity MIMO symbol detection [PDF]

, 2008
Detection of spatially multiplexed data transmissions subject to frequency flat fading is considered. Optimal decoders require knowledge of the marginal posterior distributions of the transmitted symbols, but their exact computation is not feasible for ...
R. Piechocki, Vithanage, CM, Soler Garrido, J, C. Andrieu, Piechocki, RJ, C. Vithanage, Andrieu, C, J. Soler-Garrido   +7 more
core   +1 more source