Results 71 to 80 of about 51,577 (270)

Performance Analysis and Parallel Scalability of Numerical Methods for Fractional-in-Space Diffusion Problems with Adaptive Time Stepping

We study numerical methods and algorithms for time-dependent fractional-in-space diffusion problems. The considered anomalous diffusion is modelled by the fractional Laplacian (−Δ)α, 0<α<1, following the integral definition.
Svetozar Margenov, Dimitar Slavchev
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Efficient Analysis of Time-Varying Multicomponent Signals with Modified LPTFT

EURASIP Journal on Advances in Signal Processing, 2005
This paper presents efficient algorithms for the analysis of nonstationary multicomponent signals based on modified local polynomial time-frequency transform.
Wei Yongmei, Bi Guoan
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Complexity and performance for two classes of noise-tolerant first-order algorithms [PDF]

Two classes of algorithms for optimization in the presence of noise are presented, thatdo not require the evaluation of the objective function. The first generalizes the well-known Adagrad method.
Toint, Philippe; id_orcid, Gratton, Serge, Jerad, Sadok   +2 more
core   +1 more source

A Review of Methodological Approaches for the Design and Optimization of Wind Farms [PDF]

, 2014
This article presents a review of the state of the art of the Wind Farm Design and Optimization (WFDO) problem. The WFDO problem refers to a set of advanced planning actions needed to extremize the performance of wind farms, which may be composed of a ...
Gunner Larsen, Réthoré, Pierre-Elouan, Gunner Chr. Larsen, Probst, Oliver, Oliver Probst, Krystel Castillo-Villar, Pierre-Elouan Réthoré, Herbert-Acero, José F., Larsen, Gunner Chr., Krystel K. Castillo-Villar, José F. Herbert-Acero, José Herbert-Acero, Castillo-Villar, Krystel K.   +12 more
core   +1 more source

Autoencoder-Based Reduced Order Observer Design for a Class of Diffusion-Convection-Reaction Systems

, 2021
The application of autoencoders in combination with Dynamic Mode Decomposition for control (DMDc) and reduced order observer design as well as Kalman Filter design is discussed for low order state reconstruction of a class of scalar linear diffusion ...
Alexander Schaum
core   +1 more source

Dispersion Compensation Scheme with a Simple Structure in Ultra-High-Speed Optical Fiber Transmission Systems

Photonics
With the explosive growth of global data traffic, long-distance fiber optic transmission systems are continuously evolving towards higher capacity and longer distances. However, to overcome the high complexity of fiber dispersion compensation algorithms,
Ying Wu, Ying Wang, Luhan Jiang, Jianjun Yu   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source