Results 61 to 70 of about 51,577 (270)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Dual-lattice ordering and partial lattice reduction for SIC-based MIMO detection [PDF]
, 2009 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2009 IEEE. Personal use of this material is permitted.
Mow, WH +5 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Traceability of performance between two ocean biogeochemistry models of differing complexity [PDF]
, 2013 A diverse range of candidate ocean biogeochemistry models exists for addressing scientific questions of societal importance in an Earth system context. Limitations imposed by computer resources favour the use of simpler models.
Hemmings, J.C.P.
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
First-Order Objective-Function-Free Optimization Algorithms and Their Complexity [PDF]
, 2022 A class of algorithms for unconstrained nonconvex optimization is consideredwhere the value of the objective function is never computed. The classcontains a deterministic version of the first-order Adagrad method typicallyused for minimization of noisy ...
Gratton, Serge +3 more
core +1 more source
Experimental Results of Novel DoA Estimation Algorithms for Compact Reconfigurable Antennas
International Journal of Antennas and Propagation, 2017 Reconfigurable antenna systems have gained much attention for potential use in the next generation wireless systems. However, conventional direction-of-arrival (DoA) estimation algorithms for antenna arrays cannot be used directly in reconfigurable ...
Henna Paaso +6 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
FRAMEWORK FOR COMPARING SEGMENTATION ALGORITHMS [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 The notion of a ‘Best’ segmentation does not exist. A segmentation algorithm is chosen based on the features it yields, the properties of the segments (point sets) it generates, and the complexity of its algorithm. The segmentation is then assessed based
G. Sithole, L. Majola
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source