Results 211 to 220 of about 8,702,509 (349)

Belief reversals as phase transitions and economic fragility: a complexity theory of financial cycles with reflexive agents. [PDF]

Rev Evol Polit Econ, 2020
Davis J.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Colorectal cancer as a complex adaptive system: integrating the hallmarks of cancer with complexity theory. [PDF]

Front Oncol
Basbus LR.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Challenges and opportunities of complexity theory in health care systems. [PDF]

J Taibah Univ Med Sci
A'aqoulah A, El-Metwally AA, Al Khateeb B, Alammari D, Alshahrani A, Aldubikhi A, Alsulami A, Fatani F, Innab N.   +8 more
europepmc   +1 more source

Correction: Complexity theory for the modern Chinese economy from an information entropy perspective: Modeling of economic efficiency and growth potential. [PDF]

PLoS One, 2020
Yan J, Feng L, Denisov A, Steblyanskaya A, Oosterom JP.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The Role of Complexity Theory in Understanding Brain's Neuron-Glia Interactions. [PDF]

Eur J Neurosci
Di Chiano M, Milior P, Poulot-Becq-Giraudon Y, Lanfredini R, Milior G.   +4 more
europepmc   +1 more source

Complexity theory for the modern Chinese economy from an information entropy perspective: Modeling of economic efficiency and growth potential. [PDF]

PLoS One, 2020
Yan J, Feng L, Denisov A, Steblyanskaya A, Oosterom JP.   +4 more
europepmc   +1 more source

Complexity and communities: The application of complexity to community studies

, 2015
Understanding community dynamics has always been a challenge for policy-makers. Often community policy has been ineffective and wasteful. This research explores and sets out an alternative, complexity-informed approach to community studies.
Large, David
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