Results 221 to 230 of about 8,702,509 (349)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Behaviour settings, situated action and complexity theory. [PDF]

Philos Trans R Soc Lond B Biol Sci
Heft H.
europepmc   +1 more source

Complexity theory and financial regulation

Science, 2016
S. Battiston, J. Farmer, A. Flache, D. Garlaschelli, A. Haldane, H. Heesterbeek, C. Hommes, C. Jaeger, Robert M. May, M. Scheffer   +9 more
semanticscholar   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Care professionals' accounts of providing support and treatment for people with co-occurring alcohol use disorder and depression in the North East of England, UK: A qualitative study informed by complexity theory. [PDF]

PLoS One
O'Donnell A, Kaner E, Hanratty B, Gilvarry E, Wigham S, Jackson K.   +5 more
europepmc   +1 more source

Bridging the 'Two Cultures' of Research and Service: Can Complexity Theory Help? Comment on "Experience of Health Leadership in Partnering With University-Based Researchers in Canada - A Call to 'Re-imagine' Research". [PDF]

Int J Health Policy Manag, 2020
Greenhalgh T.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Intellectual property protection intensity and regional technological innovation structure: Based on the perspective of economic complexity theory. [PDF]

Heliyon
Luo Q, Zhao X.
europepmc   +1 more source

Complexity theory and public management: a ‘becoming’ field

, 2018
E. Eppel, M. Rhodes
semanticscholar   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source