Results 51 to 60 of about 26,202 (254)
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 408-420, April 2025.Abstract Objective Birth asphyxia is one of the leading causes of death for neonates worldwide. Lack of an objective cost effective test to predict poor newborn outcomes at birth affects the ability to respond appropriately. This study determined predictive values of umbilical cord arterial lactate in relation to adverse neonatal outcomes. Methods This
Elizabeth Ayebare +7 more
wiley +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective The aim of this study was to evaluate the impact of potentially life‐threatening maternal conditions (PLTCs) on functional disability at 6 months postpartum. Methods This prospective cohort study was done at 10 hospitals in Tigray, northern Ethiopia. A total of 1027 postpartum women (341 with PLTCs and 686 without) were enrolled into
Fitiwi Tinsae Baykemagn +3 more
wiley +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni +3 more
wiley +1 more source
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Underdiagnosed Complicated Plasmodium vivax Malaria in a Child: Need to Think
Iranian Journal of Parasitology, 2017 Malaria is major cause of morbidity and mortality worldwide. The highest incidence of malaria in the world is South East Asia. India is most affected country followed by Indonesia and Myanmar.
Sonu AGRAWAL
doaj
A Framework for Understanding and Evaluating Localization: The Case of HelpAge International
Public Administration and Development, EarlyView.ABSTRACT Many transnational non‐governmental organizations (TNGOs) are reevaluating their organizational forms and norms as they pursue localization. Localization itself is a contested and multifaceted concept, however, complicating the design, implementation, and evaluation of localization efforts.
Hans Peter Schmitz, George E. Mitchell
wiley +1 more source
Sickle Cell Disease: Historical Overview and Current Therapies
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde +4 more
wiley +1 more source
A Child with Severe Malaria Presenting with Acute Surgical Abdomen (Duodenal Perforation)
Case Reports in Pediatrics, 2016 Plasmodium falciparum, the commonest cause of severe malaria in children, is an important cause of mortality in developing nations like Nepal. Duodenal perforation in a case of complicated malaria, although a rare entity, can occur in children.
Tika Ram Bhandari +3 more
doaj +1 more source
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria
Frontiers in Immunology, 2019 In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies.
Lea-Christina Kaminski +10 more
doaj +1 more source