Results 61 to 70 of about 6,246,317 (338)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Profiling oxidative stress markers and cardiovascular complications in chronic kidney disease patients supplemented with vitamin E

Archives of Medical Science: Atherosclerotic Diseases
Introduction Cardiovascular diseases are common complications in chronic kidney disease (CKD). Oxidative stress associated with renal and metabolic dysfunctions is one of the cardiovascular complications (CVC) in haemodialysis patients.
Leila Azouaou, Mounir Adnane, Omar Chabati, Medina Arab, Toualbi Chahine, Henni Chader   +5 more
doaj   +1 more source

The posterior use of BMP-2 in cervical deformity surgery does not result in increased early complications: A prospective multicenter study [PDF]

, 2018
Study designProspective cohort study.ObjectivesTo describe the rate of short-term complications following the posterior use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in cervical deformity (CD) surgery.MethodsCD patients from 2013 to ...
Albert, Todd J, Ames, Christopher P, Bao, Hongda, Gupta, Munish, Iyer, Sravisht, Kim, Han Jo, Klineberg, Eric O, Lafage, Virginia, Mundis, Gregory M, Neuman, Brian J, Passias, Peter, Protopsaltis, Themistocles S, Smith, Justin S, The International Spine Study Group (ISSG),   +13 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

eLife, 2023
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O ...
Heon Shin, Amy Leung, Kevin R Costello, Parijat Senapati, Hiroyuki Kato, Roger E Moore, Michael Lee, Dimitri Lin, Xiaofang Tang, Patrick Pirrotte, Zhen Bouman Chen, Dustin E Schones   +11 more
doaj   +1 more source

Complications of circumcision in male neonates, infants and children: a systematic review. [PDF]

, 2010
BACKGROUND: Approximately one in three men are circumcised globally, but there are relatively few data on the safety of the procedure. The aim of this paper is to summarize the literature on frequency of adverse events following pediatric circumcision ...
Halperin, Daniel, Larke, Natasha, Schenker, Inon, Weiss, Helen A   +3 more
core   +2 more sources

Effect of Ear Infections on Hearing Ability: A Narrative Review on the Complications of Otitis Media [PDF]

, 2022
Abdullah Jamal, Abdulla Alsabea, Mohammad Tarakmeh   +2 more
openalex   +1 more source

Obesity and inflammation: the linking mechanism and the complications

Archives of medical science : AMS, 2016
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis ...
Mohammed S. Ellulu, I. Patimah, H. Khaza’ai, A. Rahmat, Y. Abed   +4 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Reduced Autophagy by a microRNA-mediated Signaling Cascade in Diabetes-induced Renal Glomerular Hypertrophy

Scientific Reports, 2018
Autophagy plays a key role in the pathogenesis of kidney diseases, however its role in diabetic nephropathy (DN), and particularly in kidney glomerular mesangial cells (MCs) is not very clear.
Supriya Deshpande, Maryam Abdollahi, Mei Wang, Linda Lanting, Mitsuo Kato, Rama Natarajan   +5 more
doaj   +1 more source