Results 111 to 120 of about 4,843,847 (318)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Industrial Requirements on Component Technologies for Embedded Systems

open access: yes, 2004
Software component technologies have not yet been generally accepted by embedded-systems industries. In order to better understand why this is the case, we present a set of requirements, based on industrial needs, that are deemed decisive for introducing
Anders Möller   +5 more
core   +1 more source

Algebraic specifications and refinement for component-based development using RAISE

open access: yesJournal of Computer Science and Technology, 2002
There are two main activities in Component-Based Development: component development, where we build libraries for general use, and component integration, where we assemble an application from existing components.
Elsa Clara Estévez   +1 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Driving component-based software development through quality modelling

open access: yes, 2022
S.207-224 : Ill., Lit.With the advent of the OMG's new Model Driven Architecture (MDA), and the growing uptake of the UML, the concept of model-driven development is receiving increasing attention.
Bunse, C., Wüst, J., Atkinson, C.
core  

Citizen Participation in the Activities of the Inter-American Development Bank [PDF]

open access: yes, 2000
The present document sets forth the basic concepts and guidelines that would be incorporated into the Strategic Framework on Participation. It is based on the preliminary study done in the Sustainable Development Department (SDS): "Towards a Conceptual ...
Inter-American Development Bank
core   +1 more source

The artifacts of component-based development

open access: yesCoRR, 2012
Component based development idea was floated in a conference name "Mass Produced Software Components" in 1968 [1]. Since then engineering and scientific libraries are developed to reuse the previously developed functions. This concept is now widely used in SW development as component based development (CBD).
M. Rizwan Jameel Qureshi   +1 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Component integration through built-in contract testing

open access: yes, 2022
S.159-183 : Ill., Lit.This chapter describes a technology and methodology referred to as built-in contract testing that checks the pairwise interactions of components in component-based software construction at integration and deployment time.
Groß, H.-G., Barbier, F., Atkinson, C.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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