Results 201 to 210 of about 1,173,701 (313)

Intelligent techniques for predictive analytics in Agile software development. [PDF]

Sci Rep
Shankar SP, Chaudhari SS, Mishra V, Stephan T.   +3 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Diversity Analysis of Global White Clover (<i>Trifolium repens</i> L.) Germplasm Based on Agronomic and Photosynthetic Traits and SLAF-Seq Technology. [PDF]

Int J Mol Sci
Sang R, Noor M, Feng G, Han M, Feng Y, Mao P, Yan X, Meng L.   +7 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

GnRH Regulates Sex Differentiation in <i>Sebastes schlegelii</i> Through TGF-β/MAPK Signaling Pathways. [PDF]

Biology (Basel)
Huang J, Xu P, Xiao Y, Li J.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Development of the authentication and authorization processes for the iAgree portal, a platform for patient-controlled data sharing across health systems. [PDF]

JAMIA Open
Soohoo SL, Keller MS, Chen Y, Hu D, Huang SC, Kuo TT, Leder C, Lu X, Meeker D, Morse B, Moyse H, Nagaraj G, Nguyen AT, Schilling LM, Soares A, Whooley MA, Zheng K, Ohno-Machado L.   +17 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Population Structure Analysis and Candidate Gene Screening for Twinning Trait in Simmental Cattle. [PDF]

Animals (Basel)
Ma K, Liang X, Xu L, Li X, Zhao H, Huang J, Wen J, Zhang M, Wang D, Huang X, Chen Q.   +10 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source