Results 161 to 170 of about 2,006,814 (315)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Deriving safety cases for hierarchical structure in model-based development
Model-based development and automated code generation are increasingly used for actual production code, in particular in mathematical and engineering domains.
Fischer, Bernd +2 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The longitudinal structure of cognition in the ABCD study and associations with neural function and psychopathology: A Bayesian probabilistic principal components analysis. [PDF]
Dev Cogn NeurosciLuciana M, Duffy KA, Thompson WK.
europepmc +1 more source
Component-based software development with component variants
, 2007 Variants are the new units suggested for component-based software implementation to contain just one set of features that a traditional component might normally contain. They help us to implement the specialization of components without the need for long inheritance trees and strong dependencies in object oriented counterpart.
Altunel, Yusuf, Tolun, Mehmet R.
openaire +2 more sources
Component-Based Approach in Learning Management System Development
The paper describes component-based approach (CBA) for learning management system development. Learning object as components of e-learning courses and their metadata is considered.
Bule, Jekaterina +2 more
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source