Results 51 to 60 of about 608,403 (284)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Task-dependent modulation of effective connectivity within the default mode network

open access: yesFrontiers in Psychology, 2012
The default mode network (DMN) has recently attracted widespread interest. Previous studies have found that task related processing can induce deactivation and changes in the functional connectivity of this network.
Baojuan eLi   +5 more
doaj   +1 more source

Connectivity-Preserving Swarm Teleoperation With A Tree Network

open access: yes, 2019
During swarm teleoperation, the human operator may threaten the distance-dependent inter-robot communications and, with them, the connectivity of the slave swarm. To prevent the harmful component of the human command from disconnecting the swarm network,
Constantinescu, Daniela   +2 more
core   +1 more source

Concurrent determination of connected components

open access: yesScience of Computer Programming, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hesselink, Wim H.   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Characterizing Variability of Modular Brain Connectivity with Constrained Principal Component Analysis. [PDF]

open access: yesPLoS ONE, 2016
Characterizing the variability of resting-state functional brain connectivity across subjects and/or over time has recently attracted much attention.
Jun-Ichiro Hirayama   +4 more
doaj   +1 more source

Components and Connections

open access: yes, 2022
An agent like <em> Builder </em> is not merely a collection of parts like <em> Find </em> , <em> Get </em> , <em> Put </em> , and all the rest. <em> Builder </em> would not work at all unless those agents were linked to one another by a suitable network of interconnections: Could you predict ...
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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