Results 141 to 150 of about 233,547 (264)

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Enantioselective effects of imazalil on banana postharvest ripening aroma revealed by integrated volatilomics, lipidomics and metabolomics. [PDF]

Food Chem X
Chen X, Zhang Y, Wu Q, Zhuang L, Yang Z, Zhang Q, Tan L, Lan W, Wang M, Ma C, Xu Z, Lyu D.   +11 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Non-targeted metabolomics reveals metabolic signatures associated with <i>Clostridioides difficile</i> virulence. [PDF]

Front Microbiol
Pan H, Zhang M, Zhao D, Wang Q, Shang H, Luo Y.   +5 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Chemical profiling of <i>Staurogyne stenophylla</i> via UPLC-HRMS and <i>in silico</i> investigation into its anti-inflammatory potential. [PDF]

Front Vet Sci
Zhang M, Wang Z, Lin S, Liu Y, Zhang Z, Xiao X, Yu G, Liu Y, Wu Q.   +8 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Integrated omics reveal a unique antibacterial mechanism of action for the small molecule HSI#6. [PDF]

Curr Res Microb Sci
Sedky H, Hamed MB, Vermeire K, Schymkowitz J, Karamanou S, Economou A.   +5 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Diffusion-Controlled Nucleation, Growth, and Self-Assembly of Silica Nanoparticles in Laminar Microfluidic Flow. [PDF]

Langmuir
Gomes NMC, Serrão FTJ, Wilges MB, Neto ABS, Domingos GHS, Cordeiro MAL.   +5 more
europepmc   +1 more source