Results 211 to 220 of about 2,013,324 (312)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The economic impact of COVID-19: a comparative cost analysis of ICU hospitalizations before and during the pandemic. [PDF]

Clinics (Sao Paulo)
Piva HH, Miethke-Morais A, Cassenote AJF, Carneiro-D Albuquerque LA, Haddad LBP.   +4 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

[Updates on Bone Grafts and Substitutes]. [PDF]

Rev Bras Ortop (Sao Paulo)
Engel EE, Gava NF, Santos MAD, Baldoino LG, Ismael LK, Modolo LFM.   +5 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

[ECoTES index of occupational safety and health (OSH) system performance: results of a pilot study in six Ibero-American countriesÍndice ECoTES de desempenho do sistema de segurança e saúde no trabalho: resultados de um estudo-piloto em seis países ibero-americanos]. [PDF]

Rev Panam Salud Publica
Benavides FG, Cornelio C, Carmenate L, Barraza D, Gimeno Ruiz de Porras D, Vives A, Rojas M, Palomo L, López-Ruiz M, Amable M, Merino-Salazar P, Silva-Peñaherrera M.   +11 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

[Cost-effectiveness of school snacks and meals in a municipality in southern Brazil]. [PDF]

Cad Saude Publica
Costa GM, Iparraguirre JS, Sarti FM, Vinholes DB.   +3 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

[Regulation of health care financing and delivery: analytic contributions from the perspective of industrial organization and the selection dilemmaRegulação do financiamento e da oferta de serviços de saúde: contribuições analíticas a partir da perspectiva da organização industrial e o dilema da seleção]. [PDF]

Rev Panam Salud Publica
Bascolo E, Houghton N, Debrott Sanchez D, Castillo-Laborde C, Sylvain A.   +4 more
europepmc   +1 more source