Results 111 to 120 of about 5,521,628 (314)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Systems Reliability and Data Driven Analysis for Marine Machinery Maintenance Planning and Decision Making

open access: yesMachines
Understanding component criticality in machinery performance degradation is important in ensuring the reliability and availability of ship systems, particularly considering the nature of ship operations requiring extended voyage periods, usually ...
Abdullahi Abdulkarim Daya   +1 more
doaj   +1 more source

Defining Development Standards for Reusable User Interface Components [PDF]

open access: yes
This paper describes a standard for development of ASP.NET user-interface components. This standard aims to assess the quality of implemented components.
Picking, Rich, Grout, Vic, Mulawa, Max
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Comparative Analysis of Business Object Approaches [PDF]

open access: yesInformatică economică, 2007
This paper presents a comparison of several technologies for developing distributed applications. The specific technologies into consideration are: one focused on COM/DCOM/COM and Microsoft technologies, Internet Explorer and ActiveX - and the other ...
doaj  

Interacting Components.

open access: yes, 2006
SystemCSP is a graphical modeling language based on both CSP and concepts of component-based software development. The component framework of SystemCSP enables specification of both interaction scenarios and relative execution ordering among components. Specification and implementation of interaction among participating components is formalized via the
Orlic, B., Broenink, Johannes F.
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Readiness of teenagers to will pressures and pedagogical conditions of their training in the course of physical training at comprehensive school. [PDF]

open access: yesPedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2011
The main components in the structure of general school students' readiness to the will pressures, such as cognitive, motivational-emotional, active are considered. 318 students f the middle school age took part in the experiment.
Dudnik I.O.
doaj  

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