Results 31 to 40 of about 5,261 (264)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Eupatorieae (Asteraceae) no Parque Estadual da Serra Dourada, Goiás, Brasil

Rodriguésia
ResumoO Parque Estadual da Serra Dourada - PESD é o segundo maior Parque do estado de Goiás, abrangendo 30.000 hectares. Com o objetivo de contribuir com um melhor conhecimento sobre a diversidade de Asteraceae no estado de Goiás realizou-se o tratamento
Rogério Neves Ribeiro, Aristônio Magalhães Teles   +1 more
doaj   +1 more source

Preliminary assessment of genetic diversity between Glebionis coronaria and G. discolor (Asteraceae) by AFLP markers

Acta Agriculturae Slovenica, 2023
Glebionis coronaria is a valuable and medicinal herb native of Mediterranean region. Recently, G. coronaria var. discolor has been elevated to the rank of species as G. discolor (d’Urv.) Cano based on morphological characteristics, distinguishing it from
Alessia GALLUCCI, Carmelo Maria MUSARELLA, Ana CANO-ORTIZ, José Carlos PIÑAR FUENTES, Ricardo QUINTO CANAS, Clizia VILLANO   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Comparison of the antioxidant activities of nonfumigated and sulphur-fumigated Chrysanthemum morifolium cv. Hang-ju induced by oxidative stress

Pharmaceutical Biology, 2021
Context The traditional drying method, sun drying, for Chrysanthemum morifolium Ramat. cv. Hang-ju (Compositae) (HJ) is widely replaced by sulphur fumigation (SF), which has an unknown effect on its efficacy.
Hongyan Ma, Shanshan Liu, Wenshan Qu, Qi Huang, Linyuan Li, Fujiang Chu, Yuyun Zhu, Xinlin Lv, Zhimin Wang, Jingjing Zhu   +9 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The Anti-Serotonin Effect of Parthenolide Derivatives and Standardised Extract from the Leaves of Stizolophus balsamita

Molecules, 2019
The presence of dominant active compounds in standardised methanol extract from the leaves of Stizolophus balsamita (S. balsamita) was examined using HPLC with a diode-array detector.
Joanna Nawrot, Marta Napierała, Kinga Kaczerowska-Pietrzak, Ewa Florek, Justyna Gornowicz-Porowska, Ewa Pelant, Gerard Nowak   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Santolina ageratifolia Bamades ex Asso (Compositae) and their relationships with S. rosmarinifolia L.

Anales del Jardín Botánico de Madrid, 1997
The status of Santolina ageratifolia Bamades ex Asso as a distinct species belonging to S. rosmarinifolia L. aggr. is vindicated. An historical approach, a revisión of the diagnostic characters and a detailed chorology of the species in Spain is ...
Silvia López Udias, Carlos Fabregat, Gonzalo Mateo   +2 more
doaj   +1 more source