Results 111 to 120 of about 458,633 (327)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Microstructure and Mechanical Behavior of CaCO3-Doped Al–Al2O3 Composite Foams Produced by Powder Metallurgy

Journal of Advanced Research in Natural and Applied Sciences
In this study, closed-cell composite metal foam production was performed using the powder metallurgy method. Therefore, 7, 12, and 17 wt.% CaCO3 as a foaming agent was added to the Al–Al2O3 powder mixture containing 5 wt.% Al2O3 after the grinding ...
Nebi Demirbağ, Serkan Abalı
doaj   +1 more source

New eco-friendly hybrid composite materials for civil construction [PDF]

, 2006
This paper concerns the development of new hybrid composite materials using granulated cork, a by-product of cork industry, cellulose pulp, from recycling of paper residues, and hemp fibres.
Camões, Aires, Eires, R., Fangueiro, Raúl, Jalali, Said, Nunes, J. P.   +4 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Mechanical properties of Bombyx mori silkworm silk fibre and its corresponding silk fibroin filament: A comparative study

Materials & Design, 2019
Bombyx mori silkworm silk fibre is recognized as a kind of natural biological composite materials. From the view of composite materials science, we carried out systematic tensile tests to study mechanical properties and their variations along the length ...
Shaoyong Chen, Mingyue Liu, Huiming Huang, Lan Cheng, Hong-Ping Zhao   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Analysis of effective thermal conductivity for mineral cast material structures with varying epoxy content using TPS method

Materials Research, 2013
Conventionally, cast iron is the material used for high speed machine tool structures. As an alternate material to improve the structural properties, composite materials are being used, which are known to exhibit excellent thermal and mechanical ...
A. Selvakumar, P. V. Mohanram
doaj  

Impact of Mixture Ratio on Bio-Composite Material from Bamboo and Recycled Polyethylene Terephthalate (PET)

ABUAD Journal of Engineering Research and Development
The study investigated the impact of mixture ratio on various physico-chemical and mechanical properties of a bio-composite material made from bamboo and recycled polyethylene terephthalate (PET).
Abiodun Ayodeji Ojetoye, Olutosin Olufisayo Ilori, Shalom Chitom Iwedi, Kelechi Valentine Obiechefu, Precious Arinze Okezue, Kareem Feranmi   +5 more
doaj   +1 more source

PROPERTIES OF COMPOSITE MATERIALS BASED ON MIXTURES OF EPOXY POLYMERS AND OLIGOSULFONES. PART 4. ADHESION PROPERTIES

Bulletin of Belgorod State Technological University named after. V. G. Shukhov, 2020
The influence of oligosulfons with terminal carboxyl and phenolic groups and a molecular weight from 1200 to 44500 on the adhesion properties of epoxy polymers during the shift and separation of adhesive compounds is studied. It is shown that modification leads to the formation of systems characterized by improved adhesion properties, especially at ...
V. Zolotareva, Tatyana Grigorenko, Yuriy Kochergin   +2 more
openaire   +2 more sources