Results 131 to 140 of about 128,175 (304)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2015 The work presented focuses on the need to better understand the effect environmental conditions namely humidity have on the interfacial shear strength (IFSS) of composites.
Thomason, James L., Downes, Kerrie A.
core +1 more source
Journal of Manufacturing and Materials ProcessingAluminum alloy–graphene metal matrix composite is largely used for structural applications in the aerospace and space exploration sector. In this work, the preprocessed powder particles (AA 2014 and graphene) were used as a reinforcement material in a ...
Venkatraman Manokaran +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Obtenção e caracterização de compósitos de poli (éter-éter-cetona) sulfonado/níquel-fósforo com condução protônica e elétrica [PDF]
, 2012 Dissertação (mestrado) - Universidade Fderal de Santa Catarina, Centro Tecnologico, Programa de Pós-Graduação em Ciências e Engenharia de Materiais, Florianópolis, 2010O estudo e desenvolvimento de compósitos metal-polímero representa uma alternativa ...
Käfer, Karine Andrea
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Scientific ReportsThe present study aims to examine the characteristics of a composite material composed of glass/madar fibers and porcelain particles, which are reinforced with epoxy. A compression molding technique achieves the fabrication of this composite.
Thandavamoorthy Raja +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Gold nanoparticles-polyaniline composite material: Synthesis, structure and electrical properties
, 2011 Gold nanoparticles-polyaniline composite materials were synthesised and their structure and electrical properties were analised. Different stabilizing agents were used resulting in the formation of nanoparticles with sizes within 5-10 nm.
Erokhin V +4 more
core +1 more source