Results 71 to 80 of about 3,058,734 (312)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Experimental Study on the Flexural Behavior of Steel–Concrete Composite Bridge Decks with Stud–PBL Shear Connectors

Buildings
To investigate the flexural behavior of steel–concrete composite bridge decks with stud–perfobond leist (PBL) shear connectors, two specimens were designed with the stud spacing as the main variable, and static bending tests were conducted. Additionally,
Ruifeng Dou, Jun Zhao, Longhua Shi, Dongjie Weng, Ding Zhou, Wei Zhao   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Structural Design and Mechanical Behavior Investigation of Steel–Concrete Composite Decks of Narrow-Width Steel Box Composite Bridge

Buildings
Steel–concrete composite decks are commonly employed in narrow-width steel box composite girder bridges to augment their lateral spanning capabilities, while the concurrent omission of longitudinal stiffeners leads to a substantial reduction in the ...
Yunteng Chen, Yongchun Zhang, Maofeng Yu, Xiangsen Hu, Wei He, Kaiqiang Qin, Yaoyu Zhu, Xiaochen Wei   +7 more
doaj   +1 more source

A review on application of composite truss bridges composed of hollow structural section members

Journal of Traffic and Transportation Engineering (English ed. Online), 2019
Composite truss with hollow structural section (HSS) members is deemed as the structure applicable to large-span and heavily-loaded bridges. To promote the application of composite truss bridge with HSS members in China, this paper described its ...
Zhijuan Tian, Yongjian Liu, Lei Jiang, Weiqing Zhu, Yinping Ma   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Valencia bridge fire tests: Experimental study of a composite bridge under fire

, 2017
The consequences of bridge fires and the lack of guidelines on the evaluation of the fire resistance of bridges have triggered a lot of recent research. Most of these studies are based on numerical models and thus need validation by experimental studies.
J. Alos-Moya, I. Payá-Zaforteza, A. Hospitaler, P. Rinaudo   +3 more
semanticscholar   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A Dynamic Interaction Analysis of a Straddle Monorail Train and Steel–Concrete Composite Bridge

Buildings
Train–bridge dynamic interaction analysis is critical for the dynamic design of bridges and the safety and comfort assessment of trains. This study introduces a train–bridge dynamic model of a straddle monorail train and a steel–concrete composite track ...
Zhiyong Yao, Zongchao Liu, Zilin Zhong
doaj   +1 more source

Improvement on design analyses of composite steel-concrete bridges using elaborate finite element methods [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2010
In this paper, three-dimensional finite element analysis of composite steel-concrete bridges is performed to simulate theactual bridge behavior. The accuracy of the model is verified against the results acquired from a field test.
Jaturong Sanguanmanasak, Taweep Chaisomphob, Eiki Yamaguchi   +2 more
doaj