Results 51 to 60 of about 54,041 (265)

Fire behavior of composite steel truss bridge girders: numerical investigation and design strategies

Advances in Bridge Engineering
Fire pose more severe threat to steel truss bridge girders as compared to common steel plate and box bridge girders. To deeply clarify failure mechanism of fire exposed steel truss bridge girders, this paper presents an investigation on fire performance ...
Gang Zhang, Zhuoya Yuan, Yuhang Ding, Feng Xu, Chenhao Tang, Shichao Wang   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Bending performance of prefabricated ultra-thin UHPC unit plate reinforced orthotropic steel bridge decks

Frontiers in Materials
To address the challenges related to lengthy construction period, complex maintenance requirement, and the elevated risk of shrinkage cracking associated with cast-in-place UHPC reinforcement of orthotropic steel bridge decks. This paper proposes a novel
Xiang Zhou, Xiang Zhou, Jinlong Jiang, Jinlong Jiang, Le Liu, Le Liu, Shan Wang, Shan Wang, Xilei Deng, Xilei Deng, Yong Li, Yong Li, Zhongya Zhang, Zhongya Zhang   +13 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Investigation of the Mechanical Features of Steel–Concrete Composite Girder Rigid Frame Bridges with V-Shaped Piers during Construction Stages

Applied Sciences
Steel–concrete composite girder rigid frame bridges with V-shaped piers are a new type of bridge structure. Based on the traditional composite continuous beam bridge, part or all of the vertical piers are changed into V-shaped piers.
Yong Zeng, Tao Yu, Yunchuan Xiao, Weilong Li   +3 more
doaj   +1 more source

Numerical study of pedestrian suspension bridge with innovative composite deck

Heliyon, 2020
The increasing trend of using light and slender deck in pedestrian bridge has raised the issue of instability under pedestrian movement. The suspension pedestrian bridges are more vulnerable as lateral vibration often occurred in such type of bridges ...
Saima Ali, David Thambiratnam, Xuemei Liu, Sabrina Fawzia   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Endurance of the wooden bridge reinforced by the dowel plates

Studia Geotechnica et Mechanica, 2018
The most important piece of road infrastructure is bridges. Wooden bridges have advanced constantly during the past decades. The trend began in Scandinavian countries but has also now gained significant ground in Russia.
Dahoua Lamri, Boymatov Fakhridine
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source