Results 41 to 50 of about 263,645 (280)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Heat Treated NiP–SiC Composite Coatings: Elaboration and Tribocorrosion Behaviour in NaCl Solution [PDF]

, 2009
Tribocorrosion behaviour of heat-treated NiP and NiP–SiC composite coatings was investigated in a 0.6 M NaCl solution. The tribocorrosion tests were performed in a linear sliding tribometer with an electrochemical cell interface.
A Hovestad, A Miranda, C. B. Santos, C. F. Malfatti, CF Malfatti, CF Malfatti, D Landolt, E Färber, F Assi, F Bigdeli, H. Hololeczek, H. M. Veit, HG Schenzel, I Apachitei, I Garcia, I Garcia, IR Aslanyan, IR Aslanyan, J Fransaer, J Takadoum, J.-P. Bonino, JP Bonino, JP Celis, JW Graydon, KH Hou, L Fedrizzi, M Kaisheva, M Verelst, M. Metzner, N Guglielmi, P Jemmely, P Jemmely, P Ponthiaux, Q Zhao, S Mischler, S Shawki, SL Kuo, YL Shi   +37 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

In-situ TiC-reinforced Ni-based composite coatings fabricated by ultrasonic-assisted electrospark powder deposition

Journal of Asian Ceramic Societies, 2023
In this study, a (Ti + graphite)-Ni composite powder serving as a coating material was deposited on H13 steel to fabricate an in-situ TiC-reinforced Ni-based composite coating by a new type of ESD process, which was named ultrasonic-assisted electrospark
Hang Zhao, Chang Gao, Cheng Guo, Bin Xu, Xiao-Yu Wu, Jian-Guo Lei   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Non-Cyanide Electrodeposited Ag–PTFE Composite Coating Using Direct or Pulsed Current Deposition [PDF]

, 2016
The effects of FC-4 cationic surfactant on electrodeposited Ag–PTFE composite coating using direct or pulsed currents were studied using scanning electron microscope (SEM), energy dispersive X-ray (EDS), optical microscope, and a linear tribometer.
Le, Huirong, Sieh, Raymond
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Electrodeposition and Corrosion Resistance Properties of Zn-Ni/TiO2 Nano composite Coatings

International Journal of Electrochemistry, 2011
Nano sized TiO2 particles were prepared by sol-gel method. TiO2 nano particles were dispersed in zinc-nickel sulphate electrolyte and thin film of Zn-Ni-TiO2 composite was generated by electrodeposition
B. M. Praveen, T. V. Venkatesha
doaj   +1 more source

Antibacterial improvement with multilayer of bio-composite coatings produced by electrophoretic deposition [PDF]

Engineering and Technology Journal
In this study, multi-structured coatings of biocompatible and antibacterial materials on a 316L stainless steel (SS) implant have been electrophoretically deposited for orthopedic applications.
Noor AL-Ali, Makarim Abdulkareem, Iman Anoon   +2 more
doaj   +1 more source