Results 61 to 70 of about 94,918 (283)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Study of the Corrosion Resistance of a Superhydrophobic Ni-P- Al2O3 Composite Coating Based on Electrochemical Machining

International Journal of Electrochemical Science, 2019
To enhance the corrosion resistance of type 45 steel substrates, a superhydrophobic Ni-P- Al2O3 composite coating was prepared on the type 45 steel substrates with electrochemical machining.
Yin Zhang, Min Kang, Hengzheng Li, Yuntong Liu   +3 more
doaj   +1 more source

TiN protective coating on NdFeB by DC magnetron sputtering

, 2012
TiN protective coating was prepared on NdFeB by DC magnetron sputtering to improve the corrosion resistance and scratch resistance of the magnetic.
Li Jinlong, Song Zhenlun, Mao Shoudong, Xue Qunji, Li, JL   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of pyrogallol compounds dosage on mechanical properties of epoxy coating

e-Polymers
Anticorrosive coatings are considered to be one of the most economical and effective means of protection. The adhesion of the coating is defined as the strength of the interfacial bond between the coating and the substrate, which directly determines the ...
Huang Weitao, Yao Yong, Deng Jiayi, Liu Yuqi, Guo Minlong, Huang Congshu, Liang Yu, Mo Yeqiang   +7 more
doaj   +1 more source

Preparation and characterization of atmospheric plasma-sprayed NiCr/Cr3C2-BaF2 center dot CaF2 composite coating

, 2009
NiCr alloy-coated BaF2 center dot CaF2 eutectic and Cr3C2 powders were respectively prepared by both pressurized hydrogen reduction and solid state alloying technology.
Zhang, Weigang, Huang, Chuanbing, Huang, CB, Du, Lingzhong   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Study into mechanical and electrochemical properties of coating deposits and welded-coated components using the HVOF (High Velocity Oxy-Fuel) process. [PDF]

, 2007
The present study examines the metallurgical, mechanical and corrosion properties of High Velocity Oxy-Fuel (HVOF) thermal spray coatings of Inconel 625 powders on plain and welded surfaces of mild carbon and stainless steel (304).
Boudi, Adnan Abdullatif
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Preparation and properties of Mg-Nd binary alloy MAO/SiO2@α-Fe2O3 organic composite coating

npj Materials Degradation
In order to make magnesium alloys better used in aviation, electronic information and other fields, it is necessary to improve their corrosion resistance and wave absorption properties.
Qiang Sun, Quantong Jiang, Siwei Wu, Chang Liu, Heng Tang, Hao Shi, Liying Song, Jizhou Duan, Baorong Hou   +8 more
doaj   +1 more source