Results 41 to 50 of about 56,175 (267)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Volcanic cooling signal in tree ring temperature records for the past millennium

, 2013
The authors acknowledge the National Science Foundation for funding much of the research presented herein. RW's Scottish work is currently funded through the UK Leverhulme Trust and Natural Environment Research Council (NERC) projects, “RELiC ...
Anchukaitis, Kevin, Anchukaitis, Kevin J., D'Arrigo, Rosanne Dorothy, D'Arrigo, Rosanne, Rosanne D'Arrigo, Wilson, Rob, Kevin J. Anchukaitis, Wilson, Robert J., Rob Wilson   +8 more
core   +1 more source

Real-time automated composite scanning using forced cooling infrared thermography [PDF]

, 2021
The growing importance of reliable, rapid, and non-contact non-destructive evaluation (NDE) of parts/structures either during manufacturing or maintenance operations has promoted the development of real-time, automated, and in-situ methods.
Malfense Fierro, Gian Piero, Meo, Michele, Flora, Francesco, Boccaccio, Marco   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A light/water/fire-stable, cooling wood composite

Industrial Crops and Products
Passive daytime radiative cooling (PDRC) technology offers a zero-energy route to reducing temperature. Yet, many existing materials rely on petrochemical components or face practical limitations, such as flammability, hydrophilicity, and poor weather ...
Chaoqun Ji, Kaisheng Zeng, Xinxin Li, Lihui Chen, Jianguo Li, Haodong Sun, Yiqiang Wu   +6 more
doaj   +1 more source

Experimental Study on Heat Transfer and Adsorption Cooling Performance of MIL-101/Few Layer Graphene Composite

Energies, 2021
MIL-101 is a promising metal-organic frameworks (MOFs) material in adsorption chiller application due to its high adsorption capacity for water and excellent adsorption/desorption cyclic stability.
Yu Yin, Junpeng Shao, Lin Zhang, Qun Cui, Haiyan Wang   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Study on Effects of Cooling Process on Mechanical and Tribological Properties of Melt-casting Copper-Steel Bimetallic Composites

Medžiagotyra
The ZCuPb15Sn5/1045 bimetallic composites were prepared by the melt-casting composite method. The mechanical and tribological properties of the copper-steel bimetallic composites under different cooling process conditions were studied. The results showed
Xiaoliang FANG, Yanguo YIN, Shan HUANG, Ming XU, Jilin MIAO, Rongrong LI   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source