Results 121 to 130 of about 5,444,300 (333)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Distributed Stochastic Optimization over Time-Varying Noisy Network

, 2020
This paper is concerned with distributed stochastic multi-agent optimization problem over a class of time-varying network with slowly decreasing communication noise effects. This paper considers the problem in composite optimization setting which is more
Ho, Daniel W. C., Yu, Zhan, Yuan, Deming
core  

IRT-Linked Standard Errors of Weighted Composites

, 2004
In this study, we describe an approach to calculating the standard errors of weighted scores while maintaining a link to the IRT score metric, then use the approach to compare three sets of weights. Weighting a mathematics test’s multiple-choice items, short-answer items, and extended constructedresponse items to achieve a ratio of 2:2:6 on the raw ...
Childs, Ruth A., Elgie, Susan, Gadalla, Tahany, Traub, Ross, Jaciw, Andrew P.   +4 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Identification of Loading Location and Amplitude in Conductive Composite Materials via Deep Learning Method

Sensors
Current electrical self-sensing methods for composite structural health monitoring face significant limitations. Firstly, they often require complicated electrode layouts. Secondly, accurately determining both the location and amplitude of external loads
Zhen-Hua Tang, Di-Sen Hu, Jun-Rong Pan, Yuan-Qing Li, Shao-Yun Fu   +4 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Machine learning-based study of hardness in polypropylene/carbon nanotube and low-density polyethylene/carbon nanotube composites

Discover Materials
In the present work, the hardness prediction of polypropylene/carbon nanotubes (PP/CNT) and low-density polyethylene/carbon nanotubes (LDPE/CNT) composite materials, processed by microwave technique, has been explored using machine learning models i.e ...
Harshit Sharma, Gaurav Arora, Raj Kumar, Suman Debnath, Suchart Siengchin   +4 more
doaj   +1 more source

Composite Foundation Settlement Prediction Based on LSTM–Transformer Model for CFG

Applied Sciences
Roadbed construction typically employs layered and staged filling, characterized by a periodic feature of ‘layered filling—filling interval’. The load and settlement histories established during staged construction offer crucial insights into long-term ...
Zichao Li, Yipu Peng, Jian Li, Zhiyuan Tang   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Optimizing signal-to-error ratio in standing wave ultrasonic measurements [PDF]

Standing wave ultrasonic techniques for the measurement of very small changes in acoustic attenuation and phase velocity are discussed. Enhanced sensitivity to these small changes was achieved by making the specimen part of a composite ultrasonic ...
Brown, J. J., Miller, J. G., Stubblefield, V. E.   +2 more
core   +1 more source