Results 141 to 150 of about 279,015 (269)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Analytical Solution for Composite Foundation with Permeable Pipe Piles Under Uniform Opening Based on Modified Equal Strain Assumption

工程科学与技术
Composite foundation is an effective technology for treating soft ground and is widely used in engineering practices. Permeable pipe piles combine the advantages of the permeability of granular piles with the high bearing capacity of adhesive columns ...
Weitao YANG, Zheng CHEN, Yaru DUAN, Guoxiong MEI   +3 more
doaj  

Structure-mediated fluid-involved behaviors promote the performance of a carbon-based supercapacitor. [PDF]

Nanoscale Adv
Cao H, Tang C, Duan J, Yang Z, Li Y.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Analytical Models and Solutions for Consolidation of Composite Foundation with Long Prefabricated Vertical Drains and Short Stone Columns Based on Virtual Pile Method

工程科学与技术
ObjectiveThe combined composite foundation with long prefabricated vertical drains (PVDs) and short stone columns demonstrates significant engineering benefits in practical applications by integrating reinforcements with varying drainage capacities ...
XU Baolong, LU Mengmeng, ZHANG Xinyan, LIU Yuanjie   +3 more
doaj  

Seismic isolation of foundation by composite liners

, 2020
198
openaire   +1 more source

Leaf-Inspired Eutectic Skin With Extreme Fatigue Resistance and Robust Wet Adhesion for Amphibious Epidermal Electronics. [PDF]

Adv Mater
Hou J, Dong J, Kim JH, Zhou C, Lin S, Liu X, Qiu H, Zheng M, Zhang Y, Zhu H, Geng K, Peng Y, Liu H, Huang Y, Luo Y, Park S, Liu T.   +16 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Multifunctional Alginate Composite Fibers Based on Pre-Crosslinked Spinning Solutions. [PDF]

Materials (Basel)
Liu L, Zhou H, Du C.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source