Results 201 to 210 of about 279,015 (269)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Zinc-Doping Trap Engineering and FRET Synergy Enable Multicolor Room-Temperature Phosphorescence in Rice-Derived Carbon Dots Confined in Amorphous Alumina for Advanced Encryption. [PDF]

Adv Mater
Zhang X, Ren D, Wei Y, Ma H.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Roll-to-Roll AgNWs Networks/Ag Finger by Self-Masking Protection for Large-Area Monolithic Flexible Organic Solar Cells. [PDF]

Nat Commun
Han Y, Chen Z, Fang L, Yin L, Zhang L, Huang R, Gong C, Meng K, Yang Y, Yan L, Lin J, Ma CQ, Luo Q.   +12 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

A Multifunctional Cationic Waterborne Polyurethane System with High Fire-Safety and Antibacterial Performance Enabled by Phosphorous Acid-Protonated Chitosan. [PDF]

Biomimetics (Basel)
Tian XY, Zhao ZG, Chen P, Ni YP.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Mechanical and Thermal Properties of AlN-SiC Composite Ceramics Fabricated by In Situ Reaction Hot-Pressing Sintering. [PDF]

Materials (Basel)
Zhao X, Wang B, He P, Qiu S, Zhang X, Xin W, Pang J, Huang R.   +7 more
europepmc   +1 more source

Microfluidic-Assembled 3D FeF₃/rGO Composite Fabric Cathodes with Egg-roll-Like Confinement Structure for High-Rate and Long-Cycle Lithium-Ion Batteries. [PDF]

ACS Omega
An Z, Yuan P, Guan T, Hu W, Yang A, Han Y, Guo E, Chu L, Huang Z, Zhang L, Ji C, Bao N.   +11 more
europepmc   +1 more source

Design of Novel Fe-Doped NiCo-LDH/NiFeCo-Oxide Composite Nanosheets Grown on Carbon Fiber Cloth for High-Performance Flexible Asymmetric Supercapacitor. [PDF]

Materials (Basel)
Qiu W, Zhu Z, Li X, Luo H, Chen J, Wang C, Zou L.   +6 more
europepmc   +1 more source