Results 101 to 110 of about 11,482,458 (388)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Digital-Twin-Enhanced Quality Prediction for the Composite Materials

, 2023
Yu-Cheng Wang, Fei Tao, Ying Zuo, Meng Zhang, Qinglin Qi   +4 more
openalex   +1 more source

Direct 4D printing via active composite materials

Science Advances, 2017
A 4D printing method is developed where the shape of a 3D-printed part can change rapidly into a new permanent one by heating. We describe an approach to print composite polymers in high-resolution three-dimensional (3D) architectures that can be rapidly
Zhen Ding, Chao Yuan, Chao Yuan, Xirui Peng, Tiejun Wang, H. Qi, M. Dunn   +6 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A microscale modeling method for predicting the compressive behavior of 3D needled nonwoven fiber preforms

Materials & Design
The through-thickness compressive mechanism of 3D needled nonwoven fiber preforms is complicated due to the complex fiber structure and enormous fiber-to-fiber contacts.
Jing Fang, Jingjing Wang, Junbo Xie, Jinming Wang, Tongqi Li, Ying Zhang, Wei Jiao, Li Chen   +7 more
doaj   +1 more source

Reliability analysis and micromechanics: A coupled approach for composite failure prediction [PDF]

, 2011
This work aims at associating two classical approaches for the design of composite materials: first, reliability methods that allow to account for the various uncertainties involved in the composite materials behaviour and lead to a rational estimation ...
Dehmous, Hocine, Welemane, Hélène
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Mechanical Properties of a Bone-like Bioceramic–Epoxy-Based Composite Material with Nanocellulose Fibers [PDF]

, 2023
Young‐Seong Kim, Jin Woo Baek, Zheng-Yun Jin, H. C. Jeon, Min‐Woo Han, Joong Yeon Lim   +5 more
openalex   +1 more source

Controlled intermittent interfacial bond concept for composite materials [PDF]

, 1975
Concept will enhance fracture resistance of high-strength filamentary composite without degrading its tensile strength or elastic modulus. Concept provides more economical composite systems, tailored for specific applications, and composite materials ...
Atkins, A. G., Marston, T. U.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source