Results 81 to 90 of about 1,550,674 (338)

Energy bursts in fiber bundle models of composite materials

, 2008
As a model of composite materials, a bundle of many fibers with stochastically distributed breaking thresholds for the individual fibers is considered.
B. K. Chakrabarti, D. Sornette, F. T. Peirce, I. G. Scott, M. Sahimi, P. C. Hemmer, P. Fazzini, Per C. Hemmer, Srutarshi Pradhan   +8 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The study on microstructure and mechanical properties of multi-component composite based on HDPE

Designed Monomers and Polymers, 2020
The basalt fiber (BF) and polyamide 6 (PA6) reinforced HDPE composite were prepared; the effects of adding fiber, organic filler, and polar component maleic anhydride (MA) on the microstructural characteristics of composites were investigated ...
Yazhen Wang, Chenglong Wang, Shaobo Dong, Liwu Zu, Tianyu Lan   +4 more
doaj   +1 more source

Basalt short fibers dispersion and fabric impregnation with Magnesium alloy (AZ63). First results [PDF]

, 2019
Magnesium is one of the lightest structural metals used in different industrial sectors and many works in the literature have studied its reinforcement by filler addition.
Marini, Danilo, Valente, Marco
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A microscale modeling method for predicting the compressive behavior of 3D needled nonwoven fiber preforms

Materials & Design
The through-thickness compressive mechanism of 3D needled nonwoven fiber preforms is complicated due to the complex fiber structure and enormous fiber-to-fiber contacts.
Jing Fang, Jingjing Wang, Junbo Xie, Jinming Wang, Tongqi Li, Ying Zhang, Wei Jiao, Li Chen   +7 more
doaj   +1 more source

Calculating Cross Sections of Composite Interstellar Grains [PDF]

, 1999
Interstellar grains may be composite collections of particles of distinct materials, including voids, agglomerated together. We determine the various optical cross sections of such composite grains, given the optical properties of each constituent, using
Bussoletti E., Desert F. X., Henning Th., John S. Mathis, Mathis J. S., Nikolai V. Voshchinnikov, Ossenkopf V., Ossenkopf V., Stognienko R., Videen G., Wu Z. P.   +10 more
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source