Results 61 to 70 of about 1,550,674 (338)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Graphene-Skinned Fiber with Fine-Tunable Electrical Resistance via Radical and Substrate Engineering for Electromagnetic-Thermal Fabric

Nano-Micro Letters
Highlights The composition of C1/C2/C6 radicals is strategically regulated by temperature, dictating the growth of either defective or highly textured graphene microstructures.
Jie Liang, Zhaochen Li, Fang Ye, Yuchen Cao, Yi An, Xiaomeng Fan, Qiang Song   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Research progress of nitride based ceramic high temperature wave transparent materials

Journal of Aeronautical Materials, 2020
Nitride-based ceramic materials have excellent comprehensive properties such as high strength, high modulus, high temperature resistance, thermal shock resistance and wave-transparent performance.
CUI Xuefeng, LI Jianping, LI Mingxing, ZHOU Jie, LI Xin, CHENG Laifei, LIU Yongsheng, YE Fang   +7 more
doaj   +1 more source

A new concept for joining dissimilar composites [PDF]

, 1973
Bi-composite joint serves as interface between two dissimilar materials by interleaving plies of one composite with plies of another. This interleaving forms transition area between composites.
Dullea, K. C., Evangelista, J. A.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Structure and Properties of Ti-Al Intermetallic Coatings Reinforced with an Aluminum Oxide Filler

Metals
In this paper, the results of a study of the structure and phase composition of the hot-dip aluminizing coatings formed on the commercially pure titanium surface in AW-6063 aluminum alloy melt after heat treatment at 700 and 850 °C are presented.
Artem Igorevich Bogdanov, Vitaliy Pavlovich Kulevich, Victor Georgievich Shmorgun, Leonid Moiseevich Gurevich   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Broadband electromagnetic absorption up to 1473 K enabled by dielectric frequency-dispersion engineering in ceramic composites

Nature Communications
Rising vehicle Mach numbers urgently necessitate broadband electromagnetic wave (EMW) absorbers capable of operating at even higher temperatures while maintaining environmental durability.
Bin Ren, Yujun Jia, Lehua Qi, Qiangang Fu, Yixiang Lin, Hang Yu, Junjie Cheng, Mengyu Dai, Qiang Song, Yulei Zhang, Xianghui Hou, Hejun Li   +11 more
doaj   +1 more source

Formation of Ti-Cu-Ni Intermetallic Coatings on Titanium by Laser Processing of an Explosively Welded Layered Composite

Journal of Manufacturing and Materials Processing
This study investigates the influence of design factors and key process parameters—including explosive welding (EXW), rolling, and laser processing—on the formation, microstructure, and tribological properties of Ti–Cu–Ni intermetallic coatings.
Artem Igorevich Bogdanov, Vitaliy Pavlovich Kulevich, Leonid Moiseevich Gurevich, Victor Georgievich Shmorgun   +3 more
doaj   +1 more source